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LipoSEARCH for Lipoprotein Particle Size Analysis

Watching good and bad cholesterol and triglyceride is insufficient for prevention, early detection and treatment of lifestyle related diseases such as diabetes and hyperlipidemia. The specialists recommend to check out the level of small, dense LDL because small particle size LDL is the most common cause of atherosclerosis. This indicates the significance of measuring particle size in lipoprotein profile testing.

LipoSEARCH is a lipoprotein profiling service to analyze the size of lipoprotein particle and the level of cholesterol and triglyceride on each of 20 subclasses. The attached wave-form chart (chromatogram) helps you to visually see overall changes or differences in lipoprotein profiles caused by medication and clinical state.

Visual Differences between the Normal and Patients

Healthy human(adult male)   Diabetic patient
  VLDL peak of TG is characteristic of diabetic patients. VLDL, which is rich in TG, increases as TG metabolism decreases due to lower LPL activity.
   
Patient with hyperlipidemia Patient with a low HDL level
VLDL and LDL cholesterol increased. No HDL peak is observed.

Benefits of Analyzing Subclasses – CAD & Non-CAD

The table below shows the differences between CAD and Non-CAD in the data of subclasses such as small LDL.

Benefits of Analyzing Particle Size – Metabolic Syndrome

Correlation of LDL-C Subclasses with VFA/SFA by CT Scan

Visceral fat area (VFA) shows certain correlation with small LDL-Cho and very small LDL-Cho, while subcutaneous fat are shows no such correlation. LipoSEARCH helps recognize potential risk of metabolic syndrome.

Correlation between Lipoprotein Subclasses and Clinical Markers

LipoSEARCH subclass analysis is very helpful for detecting minute abnormalities in lipid metabolism, thus being used for diagnosing and determing risks for a broad range of diseases.

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